A conjugate comprising cholesterol linked to tetracycline
CA 2791165 C · Owner: West Virginia University · Inventors: Quattrone, Alessandro; Nelson, Thomas J.; Alkon, Daniel L.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
This invention relates to a highly efficient artificial low-density lipoprotein (LDL) carrier system for the targeted delivery therapeutic agents across the blood-brain barrier (BBB). In particular this invention relates to artificial LDL particules comprised of three lipid elements: phosphatidyl choline fatty-acyl-cholesterol esters, and at least one apolipoprotein. The present invention further relates to compositions methods and kits comprising artificial LDL particules for targeting drugs to and across the BBB for the prevention and treatment of brain diseases. Moreover the present invention is directed to a conjugate formed by ester linkage between cholesterol and a therapeutic agent.
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 2, 2003 and granted February 24, 2015. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended December 2, 2023.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 2, 2025.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.