Copolymers for suppression of autoimmune diseases, and methods of use
CA 2768340 C · Owner: President And Fellows Of Harvard College · Inventors: Strominger, Jack L.; Fridkis-Hareli, Masha
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Random three- and four-amino acid copolymers having lengths of 14- 35- and 50-amino acid residues are provided. Fifty-mers of FEAK were effective inhibitors of MBP 85-99 or proteolipid protein (PLP) 40-60-specific HLA-DR-2- restricted T cell clones. These copolymers efficiently suppressed EAE induced in susceptible SJL/J (H-2S) strain of mice with either whole spinal cord homogenate (WSCH) or with the encephalitogenic epitope PLP 139-151. YFAK 50-mer having a molar ratio of about y 0.8:F 0.2 inhibited binding of biotinylated MBP 85-99 epitope to HLA-DR-2 molecules more efficiently than either unlabeled MBP 85-99 or Copaxone®. YFAK and FAK copolymers efficiently suppressed EAE induced in …
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed October 3, 2002 and granted June 30, 2015. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended October 3, 2022.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 3, 2024.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.