Regulation of hematopoietic stem cell differentiation by the use of human mesenchymal stem cells
CA 2680649 A1 · Owner: Thiede, Mark A. · Inventors: Thiede, Mark A.; Mbalaviele, Gabriel
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The invention relates to the induction of hematopoietic stem cells to differentiate into , osteoclasts by culturing hematopoietic stem cells with human mesenchymal stem cells, and, in a preferred embodiment, using no exogenous cytokines. Differentiation of the , mesenchymal stem cells into osteoblasts inhibited the differentiation of hematopoietic , stem cells into osteoclasts. In addition hematopoietic stem cells can be , genetically engineered to carry genes of interest particularly for the expression of physiologically , active proteins. In the presence of mesenchymal stem cells the transduced , cells carry the , new
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed June 8, 1999. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended June 8, 2019.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by June 8, 2021.
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Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.