Chromatographic method for high yield purification and viral inactivation of antibodies
CA 2676074 C · Owner: Paul, Hanss-Ingolf · Inventors: Lee, Doug C.; Paul, Hanss-Ingolf; Alred, Patricia
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
An improved process for the purification of antibodies from human plasma or other sources is disclosed. The process involves suspension of the antibodies at pH 3.8 to 4.5 followed by addition of caprylic acid and a pH shift to pH 5.0 to 5.2. A precipitate of contaminating proteins lipids and caprylate forms and is removed while the majority of the antibodies remain in solution. Sodium caprylate is again added to a final concentration of not less than about 15 mM. This solution is incubated for 1 hour at 25°C to effect viral inactivation. A precipitate (mainly caprylate) is removed and the clear solution is diluted with purified water to reduce ionic strength. Anion exchange chromatography …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed May 29, 1998 and granted October 6, 2015. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended May 29, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by May 29, 2020.
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.