Use of an immunoglobulin-producing cell line to gererate diversity in a gene or gene product
CA 2675802 A1 · Owner: Medical Research Council · Inventors: Cumbers, Sarah Jane; Neuberger, Michael Samuel; Sale, Julian Edward
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The invention relates to a method for preparing an antibody-producing cell line capable , of directed constitutive hypermutation of a specific nucleic acid region comprising the , steps of: a) screening a clonal cell population for V gene diversity; b) isolating one or , more cells which display V gene diversity and comparing the rate of accumulation of , mutations in the V genes and other genes of the selected cells; and c) selecting a cell in , which the rate of V gene mutation exceeds that of other gene mutation.
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed October 8, 1999. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended October 8, 2019.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 8, 2021.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.