Human antibodies that bind human il-12 and methods for producing

Abstract From the Canadian patent

Human antibodies, preferably recombinant human antibodies that specifically , bind to , human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 , and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a , full--length antibody or an antigen-binding portion thereof. The antibodies or antibody portions, of , the inveniton are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g. in a human , subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors , and host cells for expressing the recombinant human antibodies of the invention, and methods of , synthesizing …