Stabilization of solid thyroid drug formulations

Abstract From the Canadian patent

The invention provides a drug dosage form prepared by compression techniques comprising: a substantially non- volatile pharmaceutically acceptable oil, a pharmaceutically acceptable excipient and a thyroid drug treated with the substantially non-volatile pharmaceutically acceptable oil to substantially waterproof the thyroid drug; the drug dosage form prepared by: (a) dispersing the thyroid drug and the exciepient in the substantially non-volatile pharmaceutically acceptable oil; and (b) compacting the thyroid drug into dosage forms using compression pressures of up to 5,000 psi/g. The dosage form may be used for treating a patient in need of thyroid replacement therapy.