Use of conjugates with linkers cleavable by photodissociation or fragmentation for mass spectrometry analysis of tissue sections
CA 2611266 C · Owner: Centre National De La Recherche Scientifique (Cnrs) · Inventors: Proess, Gottfried; Rudloff, Ivo; Tabet, Edmond Jean-Claude
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The invention concerns a method for determining at least one target molecule map in a tissue section, using at least one (A-X)n-B conjugate wherein A is a , tag molecule of known molecular weight X is a linker that is cleaved during , sample desorption/ionization n is an integer of at least l,and B is a binding molecule that binds specifically to said target molecule. When using MALDI mass spectrometry, said linker molecule X may be cleaved by photodissociation during sample laser irradiation if photocleavable at the wavelength of said MALDI laser. Alternatively, when using UV- MALDI IR-MALDI, SIMS or DESI mass , spectrometry said linker molecule X may be cleaved by fragmentation …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed June 7, 2006 and granted November 24, 2015. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended June 7, 2026.
- Certificates of supplementary protection extend only drug patents, and it isn't classified as one.
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