A biomimetic process for coating substrates with a biomimetic solution containing a bioactive substance and use of said process and substrates in bone-, connective tissue-, fat tissue- and muscle tissue engineering

Abstract From the Canadian patent

The invention relates to a biomimetic process for coating a substrate particularly a medical device, with a biomimetic composition which comprises: , a) producing batchwise in a closed system an acidified biomimetic composition comprising a saline aqueous mixture containing calciummagnesium-, phosphate-, bicarbonate ions and a bioactive substance b) contacting the substrate with , said biomimetic composition and c) storing the biomimetic composition in contact with the substrate and allowing a gradual increase of the pH to occur and to cause precipitation of salts and co-precipitation of the bioactive substance on said substrate and to obtain a coated substrate.