Method of coating stents to improve the stability of the therapeutic agent contained therein

Abstract From the Canadian patent

Processes for coating implantable medical devices that improve the stability of therapeutic agents contained within the coating. In one embodiment the , process comprises: applying a primer coating on the implantable medical device; preparing a basecoat solution comprising polymers and a therapeutic agent and applying the basecoat solution to the implantable medical devices; preparing a topcoat solution comprising at least one polymer and applying the topcoat solution to the implantable medical devices coated with the basecoat solution; applying a solvent to partially redissolve the topcoat and basecoat while altering the surface finish and dissolution properties of the therapeutic …