Nicotinic acid compositions for treating hyperlipidemia and related methods therefor

Abstract From the Canadian patent

An oral dosage sustained release pharmaceutical formulation for use once per day during the evening or at night or before bedtime, as a single dose, has use in daily treatment of hyperlipidemia in a patient without inducing treatment-limiting , liver damage, the formulation comprises a compressed blend of nicotinic acid in a hydrophilic matrix which controls delivery of the nicotinic acid; the, compressed blend comprises agglomerates and contains an effective antihyperlipidemic amount of nicotinic acid a swelling agent, a granulation, binder and a lubricant; the swelling agent is a hydrophilic polymer which on initial wetting starts to partially hydrate forming a gel layer such that as , …