Modified macromolecules and methods of making and using thereof

Abstract From the Canadian patent

Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking by introduction of at least one hydrazidereactive group and /or aminooxy-reactive group and methods of making and , using thereof for scar-free wound healing for delivering bioactive agents or , living cells for preventing adhesion after a surgical procedure or for bone and cartilage repair. The macromolecule can be an oligonucleotide a necleic , acid, a polypeptide, a lipid a glycoprotein, a glycolipid, a polysaccharide a protein or a synthetic polymer, preferably a glycosaminoglycan like hyaluronan.