Selection system containing non-antibiotic resistance selection marker
CA 2538863 C · Owner: Laht, Silja · Inventors: Tenson, Tanel; Ustav, Mart; Toots, Urve
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A selection system free of antibiotic resistance genes which is based on the , use of an araD gene as a selection marker carried on a vector which is inserted in a bacterial strain deficient of the araD gene. The araD gene from E. coli encodes the L-ribulose-5-phosphate-4-epimerase. A method of selecting the cells transformed with a plasmid, which contains the araD gene. The nonantibiotic selection marker makes the system suitable for producing therapeutics. The araD gene is not essential for growth of the host but manipulation of it affects the growth under certain selective conditions. Deletion of araD leads to accumulation of substance which is toxic to the host but not to humans. …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed September 15, 2004 and granted May 29, 2012. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended September 15, 2024.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by September 15, 2026.
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.