Derivatives of hydroxamic acid as metalloproteinase inhibitors

Abstract From the Canadian patent

Compounds of formula (I) are inhibitors of matrix metalloproteinases and are , of use in the treatment of, for example fibrotic disease multiple sclerosis, emphysemia, bronchitis and asthma: formula (I) wherein Ar represents an optionally substituted aryl, heteroaryl C3-C8 cycloalkyl or heterocycloakyl , group; R represents hydrogen or C1-C6 alkyl or C3-C6 cycloalkyl; Alk , represents a divalent C1-C5 alkylene or C2-C5 alkenylene radical; and R1 and R2 taken together with the nitrogen atom to which they are attached form a first heterocycloalkyl ring which is optionally fused to a second C3-C8 cycloalkyl or heterocycloalkyl ring, the said first and second rings being optionally …