Process for preparation of 4-aryl-nicotinamide derivatives
CA 2532355 C · Owner: Johnston, David A. · Inventors: Hodges, Lewis M.; Harrington, Peter John; Johnston, David A.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention relates to a process for the manufacture of compounds of general formula wherein the substituents are as described in claim I characterized in that it comprises the steps of a) reacting a compound of formula (X), with a compound of formula (Xiii) to a compound of formula , (XIVa), (XIV),b) converting the OH/=O function of compounds of formula XIV/XlVa into a leaving group P with a reagent containing a leaving group selected from the group comprising POCl3 PBr3, Mel or (F3CS02)2O to form a , compound of formula (XV) wherein P is halogen or trifluoromethanesulfonate c) substituting the leaving group P by R2 with HR2 to form a compound of formula (XVI) d) hydrolyzing …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed July 10, 2004 and granted May 15, 2012. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended July 10, 2024.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by July 10, 2026.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.