Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol

Abstract From the Canadian patent

The invention relates to techniques for measuring and comparing relative molecular flux rates of different biological molecules by administering isotope-labeled water to one or more tissues or individuals and comparing the molecular flux rates of two or more biological molecules including biological , molecules in different chemical classes. The methods find use in several applications including diagnosing, prognosing or monitoring a disease, disorder, or condition the in vivo high-throughput screening of chemical entities and biological factors for therapeutic effects in various disease models, and the in vivo high-throughput screening of chemical entities and biological factors for …