Medical devices and methods for regulating the tissue response to vascular closure devices

Abstract From the Canadian patent

Devices and methods for reducing, eliminating,preventing suppressing, or , treating tissue responses to hemostatic devices e.g. biological sealants or vascular procedures are disclosed. The invention employs a combination of resorbable, biocompatible matrix materials and a variety of therapeutic agents, such as antiproliferatives or antibiotics applied to a vascular , puncture or incision to achieve hemostasis following diagnostic or interventional vascular catheterizations and to treat neointimal hyperplasia and stenosis . A matrix of a material such as collagen provides a reservoir of a therapeutic agent such as rapamycin (sirolimus) and its derivatives and analogs for delivery at …