Anesthetic composition for topical administration comprising lidocaine, prilocaine and tetracaine

Abstract From the Canadian patent

It comprises a mixture of lidocaine, prilocaine and tetracaine or their , pharmaceutically acceptable salts. The preferred composition comprises the following components in the indicated approximate w/w percentages: 1.5% of lidocaine base; 1.5% of prilocaine base; 4% of tetracaine base; 10% of methylpyrrolidone; 2% of dimethyl sulfoxide; 0.08% of topical hyaluronidase; 1.5% of guar gum; 1 % of Tween-20; 0.5% of Tween-80 and the necessary amount , of water to 100%. It exhibits a a high concentration on skin a deep , anesthetic effect and a significantly more rapid onset of the anesthetic effect than comparable transdermal anesthetics.