5-membered heterocycle-based p38 kinase inhibitors

Abstract From the Canadian patent

Provided is a compound of the formula: (see above formula) , or a pharmaceutically acceptable salt a solvate or a hydrate thereof, wherein: R1 is hydrogen, acyl or -P(O)(OH)2; R2 is hydrogen halo, unsubstituted or , substituted alkyl alkylthio, alkylsulfinyl, alkylsulfonyl unsubstituted or substituted alkoxy, unsubstituted or substituted heterocyclyloxy, or alkylamino; G is an optionally substituted aryl, aralkyl, cycloalkyl, heteroaryl, heteroaralkyl or a heterocyclyl ring optionally fused to a , phenyl ring, or G is OR83 or NR80R81; B is aryl; C is pyrazole or imidazole; D is , heteroaryl, unsubstituted or substituted heteroaryl or -C(O)NR80R81; each R80 and R81 , is independently …