Compositions for enhancing transport of molecules into cells

Abstract From the Canadian patent

Compositions and methods for enhancing delivery of molecules e.g. biological , agents, into cells are described. The composition is a conjugate of the biological agent, preferably a, nucleic acid analog having a substantially uncharged backbone covalently , linked to a peptide, transporter moiety as described. An exemplary peptide transporter moiety has the sequence, (Arg-Y-Arg)4, where Y is 6-aminohexanoic acid. Conjugation of the peptide transporter to a, substantially uncharged nucleic acid analog such as a morpholino oligomer, is , also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.