Hepatitis c virus ns5b polymerase inhibitor binding pocket
CA 2522574 C · Owner: Laplante, Steven · Inventors: Jolicoeur, Eric; Coulombe, Rene; Poupart, Marc Andre
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The HCV NS5B polymerase, when complexed with certain inhibitors adopts a , confirmation in which the finger loop region defined by amino acid residues 18 to 35 is displaced to expose a binding pocket defined generally by amino acid residues 392, 393, 395, 396, 399, 424, 425 428, 429, 492, 493, 494, 495, 496, 500 and 503. This newly exposed binding pocket defines a novel target in the search of further chemical entities which are capable of binding to HCV NS5B and modulating, or preferably inhibiting the polymerase activity of HCV NS5B.
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed May 5, 2004 and granted July 7, 2015. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended May 5, 2024.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by May 5, 2026.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.