Method for preparation of site-specific protein conjugates
CA 2521381 C · Owner: Pr Pharmaceuticals, Inc. · Inventors: Campbell, Kathleen M.; Hinds, Kenneth; Lewis, Danny
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present invention a protein and hydrophilic , polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer. Thus the invention is directed to the , site-specific modification of selected proteins such as insulin, with , poly(ethylene glycol) at residue PheB 1. The invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed April 8, 2004 and granted May 26, 2020. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended April 8, 2024.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by April 8, 2026.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.