Pyrrolidino-1,2-dicarboxy-1-(phenylamide)-2-(4-(3-oxo-morpholino-4-yl)-phenylamide) derivatives and related compounds for use as inhibitors of coagulation factor xa in the treatment of thrombo-embolic diseases

Abstract From the Canadian patent

The invention relates to the compounds of formula (I) wherein W represents N, CR3, or a sp2 hybridized C atom, E, together with W, represents a 3- to 7-membered saturated carbocylic or , heterocyclic ring having 0 to 3 N atoms 0 to 2 O atoms and/or 0 to 2 S atoms, which ring may contain a double bond, D represents a mononuclear or binuclear unsubstituted aromatic, carbocycle or heterocycle having 0 to 4 N atoms O atoms and/or S atoms or , being , monosubstituted or polysubstituted by Hal A, OR3, N(R3)2, NO2, CN, COOR3 or , CON(R3)2 G represents -C(R4)2n-, -C(R4)2nNR3-, -C(R4)2nO- -C(R4)2nS- or -, C(R4)=C(R4)n-, X represents -C(R4)2nCONR3C(R4)2n- -C(R4)2nNR3COC(R4)2n-, -, …