Method for purification of alpha-1-antitrypsin
CA 2511986 C · Owner: Csl Behring L.L.C. · Inventors: Kee, Scott M.; Kling, Robert; Weber, David
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AATcontaining protein mixture, such as a Cohn fraction IV precipitate, is , provided. In the method of the invention contaminating proteins are , destabilized by cleavage of disulfide bonds with a reducing reagent such as a , dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material without the , addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification,without the need for extensive desalting as in prior art processes. A …
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 19, 2003 and granted February 28, 2012. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended December 19, 2023.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 19, 2025.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.