Hydrophilic cross-linking agents for use in enzymatic sensors

Abstract From the Canadian patent

An enzymatic sensor comprising an enzyme that generates a signal upon contact with an analyte; a substrate; and a cross-linking agent that comprises one or more hydrophilic moieties. The enzyme is immobilized in the substrate via the hydrophilic cross-linking agent. A biocompatible membrane comprising the , enzyme, substrate and the hydrophilic cross-linking agent is applied to a , sensor to produce an enzymatic sensor. The enzymatic sensor provides enhanced sensing capabilities by improving the diffusion of reactive species and thereby increasing the overall sensitivity and lifetime of the sensor. The incorporation of hydrophilic moieties into the cross-linking agent optimizes …