Neuroprotective activity of activated protein c is independent of its anticoagulant activity
CA 2508276 C · Owner: Zz Biotech L.L.C. · Inventors: Griffin, John H.; Zlokovic, Berislav V.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Activated protein C (APC), prodrug, and/or a variant thereof may be used as an inhibitor of apoptosis or cell death and/or a cell survival factor especially , for stressed or injured cells or tissues of the nervous system including subjects with neurodegenerative disorders. Novel biological functions (e.g. neuroprotection) can be independent or separated from inhibition of clotting or inflammation, and other biological properties of APC (e.g. antithrombotic activity, ability to reduce NFkB-regulated gene expression). It can be used in the treatment of disease or other pathological conditions by at least inhibiting the p53-dependent and/or caspase-3-dependent pro-apoptotic signaling …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 5, 2003 and granted March 27, 2018. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended December 5, 2023.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 5, 2025.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.