Method of drug loading in liposomes by gradient
CA 2506746 A1 · Owner: Yang, Stephanie · Inventors: Hu, Ning; Jensen, Gerard M.; Sulivan, Michele
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A method for encapsulation of pharmaceutical agents (e.g. antineoplastic agents) in liposomes is provided, having preferably a high drug:lipid ratio. Liposomes can be made by a process that loads the drug by an active mechanism using a transmembrane pH gradient. Using this technique trapping efficiencies , approach 100%. Drug:lipid ratios employed are higher than for older traditional liposome preparations, and the release rate of the drug from the liposomes is reduced. After loading, residual acid is quenched with a quenching agent that is base permeable at low temperatures. The residual aciditiy is thus reduced and chemical stability (e.g. against hydrolysis) is enhanced. The …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed November 26, 2003. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended November 26, 2023.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by November 26, 2025.
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.