Substituted 9a-n-n'-(benzenesulfonyl)carbamoyl-y-aminopropyland 9a-n-n'-(b-cyaneothyl)-n'-(benzenesulfonyl)carbamoyl-y-aminopropylderivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin a and 5-0-desosaminyl-9-deoxo-9-dihydro-9a-aza-homoerithronolide a

Abstract From the Canadian patent

The invention relates to substituted 9a-N-N~-(benzenesulfonyl)carbamoyl- .gamma.-aminopropyl and 9a-N-N~-(.beta.-cyanoethyl)-N~- (benzenesulfonyl)carbamoyl-.gamma.-aminopropyl derivatives of 9-deoxo-9dihydro-9a-aza-9a-homoerithromycin A and 5-O-desosaminyl-9-deoxo-9-dihydro-9aaza-9a-homoerithronolide A, novel semisynthetic macrolide antibiotics of the azalide series, of the formula (I) wherein R represents H or cladinosyl moiety, R1 represents H or .beta.-cyanoethyl group an R2 represents H or fluoro, chloro and methyl group, and pharmaceutically acceptable salts thereof with inorganic or organic acids, to the process for the preparation of pharmaceutical compositions as well as to the …