Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
CA 2502904 C · Owner: Vasquez, Maximiliano · Inventors: Tso, J. Yun; Vasquez, Maximiliano; Hinton, Paul R.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention provides for a modified antibody of class IgG in which , at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 205 314, and 428 is substituted with , another amino acid which is different from that present in the unmodified antibody, thereby altering the binding affinity for FcRn and/or the serum halflife in comparison to the unmodified antibody.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed October 15, 2003 and granted May 28, 2013. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended October 15, 2023.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 15, 2025.
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.