Method of strengthening foreign epitope presentation by mhc class i by inhibiting tap activity
CA 2500413 A1 · Owner: Tachikawa, Ai · Inventors: Tachikawa, Ai; Iwamoto, Aikichi
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A method of strengthening the presentation of a foreign epitope by MHC class I by inhibiting TAP activity. A mammalian cell-infecting viral vector encoding both of a TAP inhibitor and epitope-binding .beta.2m is constructed and transferred into mammalian cells. Thus endogenous MHC class I/peptide , complexes are decreased by the TAP inhibitor and MHC class I/peptide complexes containing epitope-binding .beta.2m expressed from the vector are successfully presented on the cell surface at a high frequency. This method is useful in the vaccine therapy for infection and cancer.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed October 1, 2003. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended October 1, 2023.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 1, 2025.
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Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.