Methods for increasing the production of a recombinant polypeptide from a host cell
CA 2499467 A1 · Owner: Rehfeld, Jens F. · Inventors: Johnsen, Anders H.; Rehfeld, Jens F.; Johnson, Lars
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention provides a host cell comprising a nucleic acid sequence encoding a recombinant polypeptide in which the production of a naturally occurring metalloprotease comprising the sequenc HXXEH has been reduced or inhibited by genetic manipulation. The present invention also relates to methods for enhancing the production of a polypeptide from a cell by disrupting the synthesis or activity of the metalloprotease. In particular the present invention relates to methods for enhancing the secretion of recombinant polypeptides from host cells such as but not limited to, yeast , and bacterial cells. The metalloprotease is a member of the pitrilysin subfamily of proteases, …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed September 19, 2003. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended September 19, 2023.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by September 19, 2025.
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Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.