Human cd3-specific antibody with immunosuppressive properties

Abstract From the Canadian patent

Described are mono- and multivalent scFv-antibodies comprising the binding sites specific for the human T cell marker CD3. These antibodies are strongly immunosuppressive and do not cause a significant release of cytokines. Furthermore, polynucleotides encoding said antibodies are described as well as vectors comprising said polynucleotides host cells transformed therewith and , their use in the production of said antibodies. Pharmaceutical compositions containing any of the above mentioned polynucleotides antibodies or vectors , are useful for immunotherapy preferably against acute transplant rejections.