Process for preparing nitrooxyderivatives of naproxen
CA 2497187 C · Owner: Nicox S.A. · Inventors: Del Soldato, Piero; Santus, Giancarlo; Benedini, Francesca
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention refers to a process for preparing a compound of general formula (A), wherein R is a radical of naproxen or bromonaproxen and R1-R12 are hydrogen or alkyl groups, m, n, o, q r and s are each independently an , integer from 0 to 6 and p is 0 or 1, and X is O, S, SO, SO2 NR13 or PR13or , an aryl, heteroaryl group said process comprising reacting a compound of formula (B) : R-COOZ wherein R is as defined above and Z is hydrogen or a cation selected from: Li+, Na+, K+, Ca++ Mg++, tetralkylammonium, tetralkylphosphonium with a compound of formula (C), as reported in the description, wherein R1-R12 and m, n, o p, q, r, s are as defined above and Y is a suitable leaving …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed August 6, 2003 and granted September 25, 2012. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended August 6, 2023.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by August 6, 2025.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.