Encapsulation of unmethylated cpg-containing oligonucleotides into virus-like particles: method of preparation and use
CA 2492826 C · Owner: Bachmann, Martin F. · Inventors: Pumpens, Paul; Maurer, Patrick; Cielens, Indulis
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances in particular with DNA , oligonucleotides containing non-methylated C and G (CpGs). Such CpG- VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition the T , cell responses against both the VLPs and antigens are especially directed to the Thl type. Antigens attached to CpG-loaded VLPs may therefore be ....sim. ideal vaccines for …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed September 16, 2002 and granted December 13, 2016. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended September 16, 2022.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by September 16, 2024.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.