Multigenic vectors plasmids and methods for increasing expression of recombinant polypeptides
CA 2492008 C · Owner: Xoma Technology Ltd. · Inventors: Horwitz, Arnold H.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention provides novel methods and materials for increasing the expression of recombinant polypeptides. Methods and materials of the invention allow increased expression of transcription units that include recombinant DNA sequences which encode polypeptides of interest. The present invention provides expression vectors which contain multiple copies of a transcription unit encoding a polypeptide of interest separated by at least one selective marker gene and methods for sequentially transforming or trasnfecting host cells with expression vectors to increase transcription unit dosage and expression.
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed March 31, 2003 and granted June 26, 2012. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended March 31, 2023.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by March 31, 2025.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.