N,n-disubstituted diazocycloalkanes useful for the treatment of cns disorders due to serotonergic dysfunction

Abstract From the Canadian patent

N,N-Disubstituted diazocycloalkanes of the formula (I): (R1 = halogen R2 = , (C3-C8)-cycloalkyl, R3 = (C1-C4)-alkoxy or (C1-C4)-haloalkoxy group m is 1 or , 2, n is 1 or 2) have affinity for serotoninergic receptors. These compounds and their enantiomers, diastereoisomers N-oxides, polymorphs, solvates and , pharmaceutically acceptable salts are useful in the treatment of patients with neuromuscular dysfunction of the lower urinary tract and diseases related to 5- HT1A receptor. 1,4-Disubstituted-piperazines (n = 1) are preferred. R1 is preferably F in the 2-position, R2 is preferably cyclohexyl and R3 is , preferably a methoxy or 2,2,2-trifluoroethyl group. Preferably m = 1.