Histone deacetylase inhibitors based on alpha-ketoepoxide compounds

Abstract From the Canadian patent

Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety for example, an alpha-ketoepoxide , group such as an alpha-ketothio group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression including , expression of genes related to tumor suppression. Accordingly inhibition of , histone deacetylase can provide an alternate route for treating cancer hematological disorders, e.g. hemoglobinopathies autosomal dominant , disorders, e.g. spinal muscular atrophy and Huntington's disease genetic , related metabolic disorders, e.g. cystic fibrosis and adrenoleukodystrophy or to stimulate hematopoietic cells ex …