Abuse-resistant opioid solid dosage form

Abstract From the Canadian patent

The present invention pertains to a solid dosage form comprising an analgesically effective amount of opioid analgesic and an opioid abusedeterring amount of a nontoxic N-methyl-D-aspartate receptor antagonist contained in a carrier which isolates, or separates the antagonist from the , opioid analgesic. The nontoxic N-methyl-D-aspartate receptor antagonist is released and made available only when the dosage form is misused as would be , the case when the dosage form is crushed or dissolved and thereafter administered in a manner other than that indicated e.g. by injection or , intranasally.