Lipid a and other carbohydrate ligand analogs

Abstract From the Canadian patent

The core structure of pentaerythritol has been used as a replacement for one or both sugars in lipid A, leading to the generation of a series of lipid A analogs. These lipid A analogs may further differ from lipid A with respect to, e.g. the number, nature and location of negatively charged groups and , the number, nature and location of the lipid chains. The lipid A analogs may be lipid A agonists useful as immunostimulatory agents or lipid A antagonists , useful in the treatment of septic shock. In a like manner a residue of , pentaerythritylamine may be used as a replacement for an amino sugar residue in a carbohydrate ligand having a biological activity of interest generating , a …