Disaccharides for drug discovery

Abstract From the Canadian patent

Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size function and other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides variously functionalised , about the sugar ring including the addition of aromaticity and charge and , the placement of pharmaceutically useful groups and isosteres.