Heterocyclic compounds which inhibit leukocyte adhesion mediated by .alpha.4 integrins

Abstract From the Canadian patent

Disclosed are compounds which bind a4 integrins preferably VLA-4. , Certain of these compounds also inhibit leukocfyte adhesion and in , particular, leukocyte adhesion mediated by a4 integrins preferably VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g. human, such as asthma Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease rheumatoid arthritis, tissue transplantation tumor metastasis and , myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis. One such compound is, (see formula I), wherein each X is independently …