Tnp-470 polymer conjugates and use thereof
CA 2480666 C · Owner: Children'S Medical Center Corporation · Inventors: Satchifainaro, Ronit; Folkman, Judah
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention relates to conjugates of water-soluble polymers and o~(chloracetyl-carbamoyl) fumagillol (TNP-470) and use of those conjugates as specific intracellular carriers of the TNP-470 into tumor vessels. The present invention further relates to use of those conjugates to lower the neurotoxicity of TNP-470. Preferably, the polymer has a molecular weight in the range of 100 Da to 800 kDa. More preferably the polymer has a molecular , weight no greater than 60 kDa. Most preferably the polymer has a molecular , weight in the range of 15 kDa to 40 kDa.
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed April 10, 2003 and granted March 6, 2012. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended April 10, 2023.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by April 10, 2025.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.