Preventive or therapeutic agent for renal disease

Abstract From the Canadian patent

A novel medicinal composition which contains as an active ingredient either a compound represented by the general formula I (wherein R1 is hydrogen or optionally substituted alkyl; R2 is dialkylamino alkyl, cycloalkyl, optionally substituted aryl etc.; T is oxygen, sulfur, etc.; Q is hydrogen or optionally substituted alkyl; and Z is hydrogen hydroxy, etc.) or a , pharmacologically acceptable salt of the compound. The medicinal composition is highly effective in inhibiting mesangial cell proliferation and lowering urinary protein and is useful for the prevention of or treatments for various kidney diseases such as IgA nephropathy diabetic nephropathy, and nephrotic , syndrome.