A non-selective cation channel in neural cells and methods for treating brain swelling
CA 2477812 C · Owner: Simard, J. Marc · Inventors: Chen, Mingkui; Simard, J. Marc
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A composition comprising a novel Ca2+-activated ATPi-sensitive nonspecific , cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar Cai. The NCCa-ATP channel is activated under conditions of ATP depletion which causes severe cell , depolarization followed by cell swelling. The NCCa-ATP channel is regulated by a sulfonylurea receptor and is inhibited by sulfonylurea compounds glibenclamide and tolbutamide. Methods employing compositions comprising the NCCa-ATP channel to screen for compounds that block the channel and the use of such …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed March 20, 2003 and granted October 14, 2014. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended March 20, 2023.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by March 20, 2025.
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