Cd40 splice variants, compositions for making and methods of using the same

Abstract From the Canadian patent

Substantially pure CD40 splice variants which include unique tail sequences fragments thereof comprising at least 10 amino acids including at least 4 amino acids of the unique tail sequence; the unique tail sequences and , homologues thereof having at least 10 amino acids and 90% identity and antibodies which bind to an epitope on such proteins are disclosed. Pharmaceutical composition comprising such protein antibodies, isolated , nucleic acid molecule that encode such proteins and pharmaceutical composition comprising such nucleic acid molecules are disclosed. The present invention relates to recombinant expression vectors which comprise such nucleic acid molecules and host cells …