Fused pyridazine derivative compounds and drugs containing the compounds as the active ingredient

Abstract From the Canadian patent

Fused pyridazine derivatives represented by the following general formula (I) (wherein each symbol is as defined in the description) and pharmaceutically acceptable salts thereof: (I) Because of inhibiting poly(ADPribose)polymerase, the compounds represented by the general formula (I) are useful as preventives and/or remedies for various ischemic diseases (in brain cord, heart, digestive tract, skeletal muscle retina, etc.), inflammatory , diseases (inflammatory bowel disease multiple cerebrosclerosis, arthritis, etc.) neurodegenerative diseases (extrapyramidal disorder Alzheimer~s , disease, muscular dystrophy lumbar spinal canal stenosis, etc.), diabetes shock, head trauma, renal …