Human monoclonal antibodies against cd30

Abstract From the Canadian patent

Isolated human monoclonal antibodies which bind to CD30 (e.g. human CD30) are disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g. a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are derivatives of the human antibodies (e.g. bispecific antibodies and immunoconjugates) pharmaceutical compositions , comprising the human antibodies non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.