Vascular stent or graft coated or impregnated with protein tyrosine kinase inhibitors and method of using same

Abstract From the Canadian patent

Disclosed is a device, such as a cardiovascular stent autologous , venous/arterial graft, prosthetic venous/arterial graft vascular catheter, or , vascular shunt for stenting a blood vessel. The device has coated thereon adsorbed thereto, impregnated therein, or covalently or ionically bonded thereto an amount of a protein tyrosine kinase inhibitor. The protein tyrosine kinase inhibitor proliferation of vascular smooth muscle cells in an area within a blood vessel immediately adjacent to and/or proximal to the device while simultaneously not inhibiting the proliferation of vascular intimal cells. A corresponding method of using the device to stent blood vessels is also disclosed.