Controlled release drug delivery composition comprising polycationic polymer and negatively charged pharmacologically active compound

Abstract From the Canadian patent

Compositions and methods for in vivo delivery of pharmacologically active agents associated with polymeric biocompatible materials. Compositions comprising a first, negatively charged pharmacologically active agent such as an oligonucleotide and a polycationic polymer such as chitosan or chitosan derivatives, optionally in a pharmaceutically acceptable carrier the composition providing controlled release and/or protection from degradation of the first, negatively charged pharmacologically active agent when introduced into the body. The pharmaceutically acceptable carrier can be a polymer paste or gel which may contain a second pharmacologically active agent which may be an …