Improvement of graft acceptance through manipulation of thymic regeneration
CA 2462046 A1 · Owner: Monash University · Inventors: Boyd, Richard
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present disclosure provides methods for inducing tolerance in a recipient to a mismatched graft of an organ, tissue and/or cells. By receiving the recipient's thymus and providing hematopoietic stem cells from the donor the , previously "foreign" matter becomes recognized as "self" in the recipient and is not rejected. the patient's T cell population is depleted. In a preferred embodiment the hemapoietic stem cells are CD34+. The recipient's thymus is reactivated by disruption of sex steroid mediated signaling to the thymus. In a preferred embodiment this disruption is created by administration of LHRH agonists, LHRH antagonists, anti-LHRH receptor antibodies anti-LHRH vaccines , …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed October 12, 2001. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended October 12, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 12, 2023.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.